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Content :

Corticosteroids & Hormones


CEPiA offers a large product portfolio of around 30 corticosteroids manufactured on a ton scale

Over the years, corticotherapy has become the reference treatment for inflammation and allergies. More recently, corticosteroids have been used in combination with anti cancer drugs.

The 1950’s were the starting point for the development and commercialization of the principal corticosteroids. Roussel Uclaf (part of Sanofi Group) has been a pioneer in this field. They have been providing the medical community with corticosteroids in various forms and doses.

Since that time and still today, Sanofi, one of the world leaders in biotechnology, keeps on offering innovative processes with fully back integrated manufacturing.

Anti-Inflammatory

Non fluorinated glucocorticoids and derivatives:
hydrocortisone, prednisone, prednisolone, methylprednisolone to treat inflammatory diseases, allergy and asthma

Fluorinated glucocorticoids and derivatives:
dexamethasone, triamcinolone, fluorometholone for the same indication at lower dosage and with a longer onset of action

For various formulations:
creams, tablets, injectables, nasal sprays and inhalers

Antihypertensives

Mineralocorticoids:
spironolactone, canrenone and potassium canrenoate used as diuretics and blood pressure regulators.

Sanofi main corticosteroids production site : Vertolaye (France)

At a glance:

  • About 300 vessels (reactors, spin dryers, …)
  • 7 chemical workshops + 1 finishing workshop (powder homogenization and micronization)
  • More than 70 APIs and hundreds of isolated intermediates
  • Successfully inspected by Health Authorities (French ANSM, FDA, PMDA, KFDA, GMED).
  • HSE and sustainable development committed (ISO 14001 certified)

Jet Milling Expertise

  • Center of expertise and industrialization for Sanofi Group
  • Homogenization capacities from one kg to one ton scales
  • A various range of particle size distributions from one micrometer to hundred micrometers
  • Class C / or class 10,000
  • Ability to handle up to OEB 4 level products